Results
English Premier League
| May 22, 2022 | ||
| Norwich City | 0 - 5 | Tottenham Hotspur |
| Chelsea | 2 - 1 | Watford |
| Brentford | 1 - 2 | Leeds United |
| Brighton & Hov… | 3 - 1 | West Ham United |
| Burnley | 1 - 2 | Newcastle United |
| Arsenal | 5 - 1 | Everton |
| Crystal Palace | 1 - 0 | Manchester United |
| Leicester City | 4 - 1 | Southampton |
| Liverpool | 3 - 1 | Wolverhampton Wanderers |
| Manchester City | 3 - 2 | Aston Villa |
| May 19, 2022 | ||
| Chelsea | 1 - 1 | Leicester City |
| Aston Villa | 1 - 1 | Burnley |
| Everton | 3 - 2 | Crystal Palace |
| May 17, 2022 | ||
| Southampton | 1 - 2 | Liverpool |
| May 16, 2022 | ||
| Newcastle United | 2 - 0 | Arsenal |
Spanish La Liga
| May 22, 2022 | ||
| Sevilla | 1 - 0 | Athletic Bilbao |
| Real Sociedad | 1 - 2 | Atlético de Madrid |
| Barcelona | 0 - 2 | Villarreal |
| Osasuna | 0 - 2 | Mallorca |
| Granada | 0 - 0 | Espanyol |
| Alaves | 0 - 1 | Cadiz |
| Elche | 3 - 1 | Getafe |
| May 21, 2022 | ||
| Valencia | 2 - 0 | Celta Vigo |
| May 20, 2022 | ||
| Rayo Vallecano | 2 - 4 | Levante |
| Real Madrid | 0 - 0 | Real Betis |
| May 15, 2022 | ||
| Celta Vigo | 1 - 0 | Elche |
| Athletic Bilbao | 2 - 0 | Osasuna |
| Atlético de Madrid | 1 - 1 | Sevilla |
| Real Betis | 2 - 0 | Granada |
| Villarreal | 1 - 2 | Real Sociedad |
| Mallorca | 2 - 1 | Rayo Vallecano |
| Getafe | 0 - 0 | Barcelona |
| Cadiz | 1 - 1 | Real Madrid |
| Levante | 3 - 1 | Alaves |
| May 14, 2022 | ||
| Espanyol | 1 - 1 | Valencia |
French Ligue 1
| May 21, 2022 | ||
| Stade de Reims | 2 - 3 | OGC Nice |
| Paris Saint-Germain | 5 - 0 | Metz |
| Nantes | 1 - 1 | Saint-Etienne |
| Marseille | 4 - 0 | Strasbourg |
| Lorient | 1 - 1 | ESTAC |
| LOSC Lille Métropole | 2 - 2 | Stade Rennais FC |
| Lens | 2 - 2 | Monaco |
| Clermont | 1 - 2 | Lyon |
| Brest | 2 - 4 | Girondins de Bordeaux |
| Angers | 2 - 0 | Montpellier Hérault SC |
| May 14, 2022 | ||
| Montpellier Hérault SC | 0 - 4 | Paris Saint-Germain |
| Girondins de Bordeaux | 0 - 0 | Lorient |
| Lyon | 3 - 2 | Nantes |
| Metz | 1 - 0 | Angers |
| Monaco | 4 - 2 | Brest |
| ESTAC | 1 - 3 | Lens |
| OGC Nice | 1 - 3 | LOSC Lille Métropole |
| Stade Rennais FC | 2 - 0 | Marseille |
| Saint-Etienne | 1 - 2 | Stade de Reims |
| Strasbourg | 1 - 0 | Clermont |
German Bundesliga
Italian Serie A
| May 22, 2022 | ||
| Venezia | 0 - 0 | Cagliari |
| Salernitana | 0 - 4 | Udinese |
| Sassuolo | 0 - 3 | AC Milan |
| Inter Milan | 3 - 0 | Sampdoria |
| Spezia | 0 - 3 | SSC Napoli |
| May 21, 2022 | ||
| Lazio | 3 - 3 | Verona |
| Fiorentina | 2 - 0 | Juventus |
| Atalanta | 0 - 1 | Empoli |
| Genoa | 0 - 1 | Bologna |
| May 20, 2022 | ||
| Torino | 0 - 3 | Roma |
| May 16, 2022 | ||
| Juventus | 2 - 2 | Lazio |
| Sampdoria | 4 - 1 | Fiorentina |
| May 15, 2022 | ||
| Cagliari | 1 - 3 | Inter Milan |
| AC Milan | 2 - 0 | Atalanta |
| SSC Napoli | 3 - 0 | Genoa |
| Bologna | 1 - 3 | Sassuolo |
| May 14, 2022 | ||
| Roma | 1 - 1 | Venezia |
| Udinese | 2 - 3 | Spezia |
| Verona | 0 - 1 | Torino |
| Empoli | 1 - 1 | Salernitana |
Dutch Eredivisie
| May 22, 2022 | ||
| Vitesse | 2 - 0 | Utrecht |
| AZ | 2 - 0 | Heerenveen |
| May 19, 2022 | ||
| Utrecht | 3 - 1 | Vitesse |
| Heerenveen | 3 - 2 | AZ |
| May 15, 2022 | ||
| Heracles Almelo | 1 - 3 | Sparta Rotterdam |
| AZ | 1 - 3 | RKC Waalwijk |
| Feyenoord | 1 - 2 | Twente |
| Groningen | 2 - 3 | Cambuur |
| NEC | 0 - 1 | Fortuna Sittard |
| Heerenveen | 3 - 1 | Go Ahead Eagles |
| PEC Zwolle | 1 - 2 | PSV Eindhoven |
| Vitesse | 2 - 2 | Ajax |
| Willem II | 3 - 0 | Utrecht |
Belgian Pro League
| May 22, 2022 | ||
| Club Brugge | 1 - 1 | Anderlecht |
| Union Saint-Gi… | 0 - 1 | Antwerp |
| May 21, 2022 | ||
| Gent | 1 - 2 | Charleroi |
| Mechelen | 0 - 0 | Genk |
| May 15, 2022 | ||
| Anderlecht | 0 - 2 | Union Saint-Gi… |
| Genk | 0 - 2 | Gent |
| Antwerp | 1 - 3 | Club Brugge |
| May 14, 2022 | ||
| Charleroi | 3 - 2 | Mechelen |
| May 12, 2022 | ||
| Anderlecht | 2 - 1 | Antwerp |
| May 11, 2022 | ||
| Club Brugge | 1 - 0 | Union Saint-Gi… |
| May 10, 2022 | ||
| Genk | 3 - 2 | Charleroi |
| Mechelen | 1 - 2 | Gent |
| May 8, 2022 | ||
| Antwerp | 0 - 4 | Anderlecht |
| Union Saint-Gi… | 0 - 2 | Club Brugge |
| May 7, 2022 | ||
| Gent | 1 - 0 | Mechelen |
| May 6, 2022 | ||
| Charleroi | 2 - 2 | Genk |
| May 1, 2022 | ||
| Anderlecht | 0 - 0 | Club Brugge |
| Antwerp | 0 - 0 | Union Saint-Gi… |
| April 30, 2022 | ||
| Charleroi | 1 - 3 | Gent |
| April 29, 2022 | ||
| Genk | 4 - 2 | Mechelen |
